I’m not exactly certain what brought Andrew Trask to St. Louis in the 1840s, but shortly after his arrival he married Ellen Weld. She died shortly after the marriage and he married again and had all his children with his second wife. Research has focused on the second wife, because that’s the one with whom he had children.
Clues as to Andrew’s origins could like in learning more about his first wife and his first marriage, particularly as it took place shortly after he arrived in St. Louis. Don’t ignore ancestral spouses that left no children behind. 
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