For those with rural ancestors, one way to potentially gather a few additional clues about relatives is to search through the probate records of their neighbors.
Your ancestor may have owed their neighbor money, borrowed money from their neighbor, inventoried the estate, purchased items from the estate, or interacted in other ways with the settlement. Those references may not be earth shattering clues.
Or they might be–it all depends on what you don’t know about the ancestor and what information is in the probate.
If nothing else, it can be interesting to discover your relative purchased something at the estate sale and how much they paid for it.